Dimethyl Sulfoxide
FUJIFILM BIOSCIENCES INC CultureSure DMSO
This product is DMSO dimethyl sulfoxide for cell culture It can be used to dissolve compounds added to culture media and to prepare cryopreservation solutions
Apexbio Technology LLC RK-33 1070773-09-9 10mM (in 1mL DMSO)
RK-33 is a small molecule inhibitor targeting DDX3 an RNA helicase frequently overexpressed in various cancer types including lung cancer DDX3 overexpression correlates with poorer survival outcomes in lung cancer patients suggesting therapeutic relevance Mechanistically RK-33 inhibits DDX3 enzymatic activity thereby disrupting downstream signaling pathways particularly the -catenin-dependent Wnt signaling axis In vitro studies indicate RK-33 induces cell cycle arrest at G1 phase promotes apoptosis and enhances cellular radiosensitivity in DDX3-high expressing cell lines (e g A549 H1299 H23 and H460 IC50 4 4 8 4 M) In preclinical in vivo testing using a Twist1/KrasG12D mouse lung cancer model combined treatment of RK-33 with radiation resulted in reduced tumor growth compared with radiation alone RK-33 serves as a research tool to investigate DDX3 biology and potential therapeutic strategies for cancers with elevated DDX3 expression
Apexbio Technology LLC Salirasib 162520-00-5 10mM (in 1mL DMSO)
Salirasib (CAS 162520-00-5) chemically known as S-trans trans-farnesylthiosalicylic acid (FTS) is a synthetic inhibitor targeting Ras proteins Structurally mimicking the carboxy-terminal farnesylated cysteine found in Ras Salirasib disrupts Ras localization at the cellular membrane thereby reducing activity of H-ras K-ras and N-ras isoforms Research indicates that Salirasib reduces Ras protein levels by approximately 50% at concentrations of 25 50 M in Panc-1 pancreatic cancer cells In xenograft models it exhibits tumor growth inhibition alone and synergistically with gemcitabine Clinical phase I studies support its continued investigation in solid-tumor therapy recommending a dose of 600 mg/day
Medchemexpress LLC Dimethyl sulfoxide | 67-68-5 | MFCD00002089 | 100.0% | 78.13 g/mol | C2H6OS | 50mL
Dimethyl sulfoxide (DMSO) (GMP Like) is the GMP Like class Dimethyl sulfoxide (HY-Y0320C) Dimethyl sulfoxide is an aprotic solvent that can dissolve water-insoluble therapeutic and toxic agents Dimethyl sulfoxide has a strong affinity for water and has the ability to rapidly penetrate or enhance the penetration of other substances through biological membranes Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity[1]
Apexbio Technology LLC BI 2536(Synonyms: BI-2536, BI2536, Plk1 inhibitor BI 2536), 10mM (in 1mL DMSO), CAS: 755038-02-9.
BI 2536 (CAS number 755038-02-9) is an ATP-competitive inhibitor selectively targeting human polo-like kinase 1 (PLK1) exhibiting an IC50 value of approximately 0 83 nM Comparatively BI 2536 shows substantially less affinity towards other kinases In vitro studies demonstrate that BI 2536 inhibits proliferation of various human tumor cell lines (EC50 values ranging from 2 to 25 nM) and induces G2/M cell cycle arrest accompanied by apoptosis as evidenced in HeLa cervical cancer cells In vivo data from xenograft tumor models indicate that BI 2536 administered intravenously on a weekly or biweekly schedule possesses antitumor efficacy
Apexbio Technology LLC Triapine 236392-56-6; 200933-27-3; 143621-35-6 10mM (in 1mL DMSO)
Triapine is a small molecule thiosemicarbazone derivative known to inhibit ribonucleotide reductase an enzyme essential for the conversion of ribonucleotides to deoxyribonucleotides thereby interfering with DNA synthesis and repair pathways Through this inhibition mechanism Triapine exhibits antitumor activity in a range of experimental cancer models including human ovarian carcinoma xenografts and murine leukemia models and inhibits proliferation across multiple tumor cell lines Due to its mechanistic specificity Triapine serves as a useful chemical tool for biomedical research into nucleic acid metabolism cancer cell replication and therapeutic resistance mechanisms
Apexbio Technology LLC KU 55933 587871-26-9 10mM (in 1mL DMSO)
KU 55933 (CAS 587871-26-9) is a selective inhibitor of ATM kinase with an IC50 of 13 nM ATM kinase promotes insulin-induced Akt activation via phosphorylation of Akt at Ser473 KU 55933 inhibition of ATM significantly reduces Akt Ser473 phosphorylation in insulin- or IGF-I-treated MDA-MB-453 and PC-3 cells resulting in suppressed proliferation cell cycle arrest at G1 phase and decreased cyclin D1 levels KU 55933 serves as a tool for studying ATM-related signaling and Akt-driven cancer cell growth regulation
Apexbio Technology LLC Valganciclovir HCl 175865-59-5 10mM (in 1mL DMSO)
Valganciclovir hydrochloride is an antiviral prodrug that undergoes rapid enzymatic conversion to the active metabolite ganciclovir after oral administration Ganciclovir inhibits viral replication by selectively targeting viral DNA polymerase thereby interfering with viral DNA synthesis and slowing cytomegalovirus (CMV) proliferation Valganciclovir is commonly utilized in laboratory studies to evaluate antiviral activity against CMV and related herpesviruses and to investigate its therapeutic potential in CMV-associated infections including retinitis and organ transplant-associated CMV infections In vitro studies report an IC50 value for valganciclovir-derived ganciclovir ranging approximately from 0 2 to 2 8 M depending on experimental cell type and viral strain
Apexbio Technology LLC Lonafarnib 193275-84-2 10mM (in 1mL DMSO)
Lonafarnib (CAS 193275-84-2) also known as SCH66336 or Sarasar is a tricyclic orally bioavailable inhibitor of farnesyltransferase (FTase) functioning without peptide or sulfhydryl groups FTase mediates post-translational farnesylation of Ras proteins a modification required for their membrane localization and activation of downstream signaling pathways involved in cellular growth proliferation and survival By inhibiting this enzymatic activity Lonafarnib disrupts Ras translocation to the plasma membrane limiting Ras-mediated signaling Currently Lonafarnib is widely evaluated in preclinical and clinical investigations particularly in oncology contexts
Apexbio Technology LLC Laquinimod (ABR-215062) 248281-84-7 10mM (in 1mL DMSO)
Laquinimod (ABR-215062 CAS 248281-84-7) is an orally bioavailable immunomodulatory small molecule Research studies demonstrate that in experimental autoimmune encephalomyelitis (EAE) a widely utilized rodent model for studying human multiple sclerosis (MS) laquinimod treatment suppresses disease progression in a dose-dependent manner Mechanistically the compound reduces inflammatory infiltration of CD4 T lymphocytes and macrophages into the central nervous system thereby modulating the Th1/Th2 immune response and inducing regulatory cytokines such as TGF- Clinical investigations into relapsing MS indicate that laquinimod administration correlates with reduced disease activity clinical relapse rate MRI-measured lesions and brain volume loss
Apexbio Technology LLC Olmesartan 144689-24-7 10mM (in 1mL DMSO)
Olmesartan (CAS 144689-24-7) is a small molecule angiotensin II receptor antagonist primarily acting by selectively blocking the binding of angiotensin II to AT1 receptors This mechanism interrupts angiotensin II-mediated vasoconstriction and aldosterone secretion resulting in antihypertensive effects In biomedical research Olmesartan serves as a valuable tool for examining hypertensive disease models elucidating angiotensin II signaling pathways and exploring therapeutic strategies targeting cardiovascular regulation
Apexbio Technology LLC Embelin 550-24-3 10mM (in 1mL DMSO)
Embelin (CAS 550-24-3) is a natural benzoquinone derivative isolated from plants of the genus Embelia functioning as an inhibitor of X-linked inhibitor of apoptosis protein (XIAP) with an IC50 value of 4 1 M XIAP negatively regulates apoptosis by inhibiting caspase activation Embelin promotes apoptosis by interrupting XIAP-caspase interaction activating apoptotic pathways in tumor cells expressing elevated XIAP levels Additionally embelin can inhibit the NF- B signaling cascade through suppression of IKK activation thereby downregulating NF- B-mediated anti-apoptotic and metastatic gene expression In animal models embelin demonstrates anti-tumor properties by attenuating tumorigenesis related to inflammation-driven colorectal cancer through modulation of IL-6/STAT3 pathway signaling
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide ACS reagent, >=99.9% | 67-68-5 | MFCD00002089 | 200L
Dimethyl sulfoxide ACS reagent, >=99.9% | Purity: >=99.9% | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 200L
