Dimethyl Sulfoxide
Medchemexpress LLC Ocedurenone 10 mM 1 mL in DMSOSolid Solvent
Ocedurenone 10 mM*1 mL in DMSOSolid + Solvent
Hampton Research 30% V/V DIMETHYL SULFOX 1ML
HR2-428-28/Additive Screen 28 (C04), 1.0 ml - 30% v/v Dimethyl sulfoxide. Please note items from this supplier are non-returnable.
Apexbio Technology LLC MK-5172 1350514-68-9 10mM (in 1mL DMSO)
MK-5172 is a selective inhibitor targeting the hepatitis C virus (HCV) NS3/4A protease an enzyme essential for viral replication The HCV virus genome encodes this protease which cleaves polyprotein precursors enabling functional viral proteins formation during replication MK-5172 inhibits protease activity across multiple HCV genotypes demonstrating IC50 values in enzymatic assays at low nanomolar concentrations In cell-based replicon systems MK-5172 exhibits IC50 values of 2 nM (genotype 1a) 0 5 nM (genotype 1b) 8 nM (genotype 2a) and 13 nM (genotype 3) MK-5172 is utilized in antiviral studies examining various genotype infections viral resistant variants and the dynamics of viral load reductions in experimental chronic infections
Apexbio Technology LLC DMXAA (Vadimezan) 117570-53-3 10mM (in 1mL DMSO)
DMXAA (Vadimezan AS-1404) is a tumor vascular disrupting and apoptosis-inducing agent functioning primarily through inhibition of DT-diaphorase (DTD) It acts by suppressing DTD enzymatic activity showing an IC50 of approximately 62 5 M Additionally DMXAA inhibits various kinases notably VEGFR2 disrupting endothelial cells and blood vessel formation to induce tumor cell apoptosis and vascular necrosis Experimentally DMXAA demonstrates activity in murine tumor models including induction of apoptosis in endothelial cells and tumor vasculature promoting necrosis and tumor regression Therefore DMXAA is commonly used in oncology research focused on anti-angiogenesis and tumor vascular disruption mechanisms
Apexbio Technology LLC CGP 57380 522629-08-9 10mM (in 1mL DMSO)
CGP 57380 (CAS 522629-08-9) is a specific and selective inhibitor targeting the serine/threonine kinase MNK1 an enzyme implicated in translation regulation via phosphorylation of the eukaryotic initiation factor 4E (eIF4E) It inhibits MNK1 activity in vitro with an IC50 of approximately 2 2 M CGP 57380 suppresses stimulus-induced phosphorylation of eIF4E in various cellular contexts including 293 cells vascular smooth muscle cells and macrophages reducing translation of mRNAs encoding proinflammatory mediators such as TNF- IL-6 and monocyte chemoattractant protein-1 (MCP-1) Hence CGP 57380 is valuable for investigating MNK1-mediated translational control in inflammation and cell signaling