Dimethyl Sulfoxide
Apexbio Technology LLC BIRB 796 (Doramapimod) 285983-48-4 10mM (in 1mL DMSO)
BIRB 796 (Doramapimod CAS 285983-48-4) is a potent inhibitor of human p38 mitogen-activated protein kinase (MAPK) which modulates the signaling pathways associated with inflammatory cytokine production It demonstrates significant inhibition of TNF- release (EC50 18 nM) in THP-1 cells In animal models oral administration reduces LPS-induced TNF- synthesis and ameliorates collagen-induced arthritis severity Clinically however trials for Crohn s disease showed no superiority over placebo BIRB 796 serves as a valuable research tool in inflammation and cytokine signaling studies
Apexbio Technology LLC Calcifediol 19356-17-3 10mM (in 1mL DMSO)
Calcifediol also termed calcidiol is a hydroxylated vitamin D3 metabolite and the primary circulating form of vitamin D3 in humans Functioning as a prehormone it undergoes further hydroxylation to calcitriol which activates vitamin D receptor (VDR) signaling pathways In vitro assays indicate that calcifediol induces CYP24A1 expression (EC50 70 nM) and thrombomodulin expression at concentrations between 10-100 nM Calcifediol dose-dependently promotes nuclear translocation of VDR at concentrations from 0 1 to 10 M in cultured cells In vivo experiments demonstrated that calcifediol administration influences calcium binding protein expression and calcium transport Clinically calcifediol administration rapidly elevates circulating 25(OH)D3 concentrations facilitating precise modulation of vitamin D status Therefore calcifediol is utilized in biomedical research related to vitamin D metabolism calcium homeostasis and VDR-associated pathways
Apexbio Technology LLC Staurosporine 62996-74-1 10mM (in 1mL DMSO)
Staurosporine is an alkaloid compound originally isolated from the bacterium Streptomyces staurospores and functions as a broad-spectrum inhibitor of serine/threonine protein kinases It potently inhibits multiple kinases including protein kinase C (PKC) protein kinase A (PKA) epidermal growth factor receptor kinase (EGF-R kinase) calmodulin-dependent protein kinase II (CaMKII) phosphorylase kinase and ribosomal protein S6 kinase Its activity against PKC exhibits an IC50 value of approximately 2 7 nM In biomedical research staurosporine is commonly employed to induce apoptosis in mammalian cancer cell lines and to investigate the roles and signaling pathways of protein kinases
Apexbio Technology LLC GLPG0634 1206161-97-8 10mM (in 1mL DMSO)
GLPG0634 (CAS 1206161-97-8) is a selective small-molecule inhibitor targeting Janus kinase 1 (JAK1) It exhibits potent inhibitory activity against JAK1 and moderate inhibition against JAK2 with reported IC50 values of approximately 10 nM and 28 nM respectively GLPG0634 preferentially interferes with signal transduction pathways mediated by JAK1 affecting cytokine-induced phosphorylation of STAT1 and STAT5 thus attenuating differentiation of Th1 Th2 and to a lesser degree Th17 cells In preclinical rat models of collagen-induced arthritis oral administration reduced inflammatory cell infiltration and bone damage supporting its potential application in inflammatory disease research
Apexbio Technology LLC BAPTA-AM 126150-97-8 10mM (in 1mL DMSO)
BAPTA-AM (CAS 126150-97-8) is a selective membrane-permeable calcium (Ca ) chelator widely utilized in biomedical research After entering cells intracellular esterases cleave BAPTA-AM releasing the active BAPTA which binds free Ca to modulate calcium-dependent cellular processes In human leukemia HL-60 and U937 cells BAPTA-AM induces apoptosis characterized by DNA fragmentation and reduced c-jun expression Additionally it inhibits voltage-gated and Ca -activated potassium currents in bovine chromaffin cells and blocks hERG Kv1 3 and Kv1 5 channels in HEK293 cells (IC 1 2 1 5 M) In mice models BAPTA-AM alters ethanol-induced behavioral responses and consumption highlighting its applicability in neuroscience and apoptosis research
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide for molecular biology | 67-68-5 | MFCD00002089 | 50ml
Dimethyl sulfoxide for molecular biology | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 50ml
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide suitable for HPLC, >=99.7% | 67-68-5 | MFCD00002089 | 12X100ML
Dimethyl sulfoxide suitable for HPLC, >=99.7% | Purity: >=99.7% | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 12X100ML
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide PCR Reagent | 67-68-5|MFCD00002089 | 1vl
Dimethyl sulfoxide PCR Reagent | Mol Wt: 78.13 | 67-68-5MFCD000020891 | vl
Apexbio Technology LLC PD98059 167869-21-8 10mM (in 1mL DMSO)
PD98059 (CAS 167869-21-8) is a selective reversible inhibitor of MAP kinase kinase (MEK/MAPK/ERK kinase) It specifically targets MEK1 affecting both basal and partially activated forms with a reported IC50 of approximately 10 M Treatment with PD98059 inhibits ERK1/2 phosphorylation in a dose-dependent manner resulting in downregulation of cyclin E/Cdk2 and cyclin D1/Cdk4 complexes In cell-based studies such as human leukemia U937 cell models treatment leads to cell growth arrest at the G1 phase and induction of apoptosis PD98059 is widely employed in research investigating signaling pathways involving ERK activation cell cycle regulation and apoptosis
Apexbio Technology LLC SCH 527123 473727-83-2 10mM (in 1mL DMSO)
SCH 527123 (CAS 473727-83-2) is a selective antagonist of chemokine receptor 2 (CXCR2) It inhibits CXCR2-mediated signaling pathways by reducing phosphorylation events within the NF- B MAPK and AKT signaling cascades In colorectal cancer cell lines SCH 527123 suppresses cell growth in a dose-dependent manner with reported IC50 values ranging from approximately 18 to 40 mol/L after a 72-hour treatment Elevated IL-8 expression in cell lines such as HCT116 and Caco2 correlates with decreased sensitivity to SCH 527123 This compound is utilized in research investigating CXCR2 signaling in inflammation and tumor growth
Apexbio Technology LLC Marimastat 154039-60-8 10mM (in 1mL DMSO)
Marimastat (CAS 154039-60-8) also known as BB-2516 is an orally bioavailable inhibitor of matrix metalloproteases (MMPs) Structurally it contains a collagen-mimicking hydroxamate moiety that facilitates covalent binding to the zinc atom at MMP active sites Marimastat exhibits broad-spectrum inhibitory activity against MMP-1 MMP-2 MMP-7 MMP-9 and MMP-14 with IC50 values of 5 nM 6 nM 13 nM 3 nM and 9 nM respectively In animal models of metastatic cancers Marimastat reduces tumor dissemination and progression Clinically Marimastat is investigated for potential therapeutic effects against metastatic and non-metastatic solid tumors such as pancreatic and gastric cancers
Apexbio Technology LLC RG7112 939981-39-2 10mM (in 1mL DMSO)
RG7112 (CAS 939981-39-2) is a selective small-molecule inhibitor of the interaction between the tumor suppressor protein p53 and its negative regulator MDM2 By blocking MDM2-p53 binding RG7112 releases and stabilizes p53 thereby enhancing the transcriptional activation of genes responsible for cell cycle arrest and apoptosis RG7112 preferentially inhibits proliferation in cancer cells harboring wild-type p53 exhibiting IC50 values ranging from 0 18 to 2 2 M whereas its efficacy diminishes significantly in p53-mutant cells RG7112 is used as a tool compound in biomedical research investigating p53-dependent antitumor mechanisms and pathways affecting hematopoiesis
Apexbio Technology LLC SP2509 1423715-09-6 10mM (in 1mL DMSO)
SP2509 (CAS 1423715-09-6) is a small molecule antagonist of lysine-specific demethylase 1 (LSD1/KDM1A) a histone-modifying enzyme responsible for demethylating mono- and dimethylated histone H3 lysine 4 (H3K4) SP2509 potently inhibits LSD1 activity (IC50 13 nM) without affecting monoamine oxidase isoforms MAO-A or MAO-B In acute myeloid leukemia (AML) cells SP2509 suppresses LSD1 function reduces colony formation induces apoptosis enhances promoter-specific H3K4 trimethylation and stimulates differentiation through upregulation of p53 p21 and C/EBP Its efficacy has been demonstrated in AML xenograft models supporting its utility as a tool compound for cancer research